NOL4

Across TCGA pan-cancer cohorts, NOL4 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated NOL4 data layer compared with 6 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher NOL4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NOL4 expression acts as an unfavorable survival marker, although some lineages such as LGG and PAAD show a favorable association.

MESO, UCEC, and LGG are the cancer types where NOL4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	II,III,IV	0.271	0.511	<.001	117	view →
UCEC	DFS	Median	All	0.571	0.701	<.001	78	view →
LGG	DFS	Tertile	All	0.861	0.747	<.001	30	view →
PAAD	DFS	Tertile	All	0.517	0.220	.001	28	view →
KIRC	DFS	Quartile	All	0.897	0.716	.007	28	view →
HNSC	OS	Median	III,IV	0.405	0.640	.006	27	view →
KIRP	DFS	Median	All	0.920	0.612	.004	20	view →
LIHC	OS	Median	All	0.740	0.637	.013	11	view →
CESC	DFS	Quartile	All	0.636	0.766	.039	10	view →
ESCA	DFS	Median	III,IV	0.427	0.225	.014	10	view →
PCPG	OS	Median	All	0.729	1.000	.015	8	view →
ACC	DFS	Tertile	All	0.135	0.507	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

NOL4–MESO (OS)

Open the MESO breakdown →