NOL4

Across TCGA cell cohorts, NOL4 mutation is significantly associated with the RNA expression of many other genes, with 370 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOL4-associated genes across cancer lineages are SNX7, ADAM2, and MAGEB4. Each is linked with NOL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOL4-to-partner and partner-to-NOL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNX7 grouped by NOL4-low versus NOL4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOL4→partner) and Y-score (partner→NOL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SNX7 →	+0.709	+2.714	.001	.002	3	2
URINARY_TRACT	ADAM2 →	+0.087	+4.217	.006	.005	3	1
URINARY_TRACT	MAGEB4 →	+0.005	+4.087	<.001	.009	3	1
URINARY_TRACT	PSMA8 →	+1.118	+4.584	<.001	.002	3	1
URINARY_TRACT	DTHD1 →	+0.042	+4.087	<.001	.009	3	1
URINARY_TRACT	LORICRIN →	+0.061	+4.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 370 associations by consensus.

SNX7 by NOL4 expression — LARGE_INTESTINE

Explore this box plot interactively →