NOL3

Across TCGA cell cohorts, NOL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,298 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NOL3-associated GO terms across cancer lineages are Regulation of hypoxia-induced intrinsic apoptotic signaling pathway, Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway, and Striated muscle cell apoptotic process. Each is linked with NOL3 in more than 16 cancer types. Because this analysis shows association rather than direction, both NOL3-to-partner and partner-to-NOL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hypoxia-induced intrinsic apoptotic signaling pathway grouped by NOL3-low versus NOL3-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOL3→partner) and Y-score (partner→NOL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of hypoxia-induced intrinsic apoptotic signaling pathway →	+0.120	+0.887	<.001	<.001	2	17
CNS	Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway →	+0.120	+0.887	<.001	<.001	2	17
KIDNEY	Striated muscle cell apoptotic process →	+0.224	+1.521	<.001	<.001	3	13
KIDNEY	Cardiac muscle cell apoptotic process →	+0.224	+1.521	<.001	<.001	3	13
LIVER	Positive regulation of G2/MI transition of meiotic cell cycle →	-0.122	-1.051	.001	<.001	3	12
LIVER	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.129	-0.993	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,298 associations by consensus.

Regulation of hypoxia-induced intrinsic apoptotic signaling pathway by NOL3 expression — CNS

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