NOD2

Across TCGA pan-cancer cohorts, NOD2 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated NOD2 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NOD2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NOD2 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC are the cancer types where NOD2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	1.000	0.625	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

NOD2–LSCC (DFS)

Open the LSCC breakdown →