NOD2

Across TCGA pan-cancer cohorts, NOD2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NOD2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NOD2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NOD2 is over-expressed in tumor, although a few such as PAAD and PRAD show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where NOD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.470	<.001	12	view →
COAD	Male	II,III,IV	+1.229	<.001	10	view →
KIRP	Male	All	+0.690	<.001	9	view →
THCA	All	IV	+0.840	.001	7	view →
BRCA	All	All	+1.055	<.001	6	view →
READ	All	All	+1.390	<.001	5	view →
BLCA	Male	All	+1.406	.010	3	view →
LIHC	All	II,III,IV	+0.283	.011	3	view →
CHOL	All	All	+0.990	.001	2	view →
PAAD	Female	All	−0.860	.047	2	view →
HNSC	All	All	+0.496	.022	2	view →
UCEC	All	All	+0.440	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NOD2–KIRC

Open the KIRC breakdown →