NOD2

Across TCGA patient cohorts, NOD2 mutation is significantly associated with the RNA expression of many other genes, with 3,589 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOD2-associated genes across cancer lineages are HIRIP3, RMND1, and SUPV3L1. Each is linked with NOD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NOD2-to-partner and partner-to-NOD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIRIP3 grouped by NOD2-low versus NOD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOD2→partner) and Y-score (partner→NOD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HIRIP3 →	+0.316	+2.110	.007	<.001	3	3
UCEC	RMND1 →	+0.464	+1.705	<.001	.005	3	3
SKCM	SUPV3L1 →	+0.332	+2.250	.004	.005	3	3
UCEC	LZIC →	+0.402	+1.648	.003	.001	3	3
UCEC	C1orf52 →	+0.280	+1.454	.003	.003	3	3
UCEC	PMPCA →	+0.313	+2.131	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,589 associations by consensus.

HIRIP3 by NOD2 expression — UCEC

Explore this box plot interactively →