NOD2

Across TCGA cell cohorts, NOD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,541 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NOD2-associated GO terms across cancer lineages are Cellular response to peptidoglycan, Regulation of myoblast fusion, and Adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Each is linked with NOD2 in more than 9 cancer types. Because this analysis shows association rather than direction, both NOD2-to-partner and partner-to-NOD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to peptidoglycan grouped by NOD2-low versus NOD2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOD2→partner) and Y-score (partner→NOD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Cellular response to peptidoglycan →	-0.251	-1.478	<.001	<.001	3	10
BONE	Regulation of myoblast fusion →	+0.088	+0.219	.001	.002	3	10
BREAST	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.056	-1.098	<.001	<.001	3	9
STOMACH	Regulation of syncytium formation by plasma membrane fusion →	+0.141	+0.702	<.001	.005	2	10
CNS	Negative regulation of myoblast fusion →	+0.085	+0.281	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	MHC class I protein complex assembly →	+0.096	+0.572	.001	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,541 associations by consensus.

Cellular response to peptidoglycan by NOD2 expression — BREAST

Explore this box plot interactively →