NOD2

Across TCGA cell cohorts, NOD2 mutation is significantly associated with the RNA expression of many other genes, with 237 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOD2-associated genes across cancer lineages are PPIAL4D, KNCN, and TRIM49. Each is linked with NOD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOD2-to-partner and partner-to-NOD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4D grouped by NOD2-low versus NOD2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOD2→partner) and Y-score (partner→NOD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PPIAL4D →	+0.114	+3.747	.001	.008	3	2
KIDNEY	KNCN →	+0.007	+4.491	<.001	.002	3	1
KIDNEY	TRIM49 →	+0.024	+4.121	<.001	.006	3	1
KIDNEY	KRTAP10-2 →	+0.027	+4.954	<.001	<.001	3	1
KIDNEY	PPIAL4F →	+0.122	+4.121	<.001	.006	3	1
OVARY	ADIG →	+0.028	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 237 associations by consensus.

PPIAL4D by NOD2 expression — SKIN

Explore this box plot interactively →