NOD1

Across TCGA pan-cancer cohorts, NOD1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated NOD1 data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher NOD1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NOD1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

THYM, HNSC, and KIRC are the cancer types where NOD1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
HNSC	DFS	Median	II,III,IV	0.078	0.695	<.001	18	view →
KIRC	OS	Median	All	0.249	0.805	.010	12	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
LUAD	DFS	Median	IV	0.045	0.717	<.001	12	view →
SKCM	DFS	Median	All	0.153	0.761	<.001	12	view →
BLCA	DFS	Median	All	1.000	0.329	.027	11	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
ESCA	DFS	Median	II,III,IV	0.080	0.495	<.001	9	view →
UCEC	DFS	Median	All	0.932	0.605	.009	8	view →
PRAD	DFS	Median	All	0.077	0.776	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

NOD1–THYM (OS)

Open the THYM breakdown →