NOD1

Across TCGA pan-cancer cohorts, NOD1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NOD1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NOD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NOD1 is over-expressed in tumor, although a few such as LUSC and BRCA show the opposite, repressed pattern.

THCA, HNSC, and KIRC are the cancer types where NOD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+2.745	<.001	11	view →
HNSC	Female	III,IV	+1.071	<.001	11	view →
KIRC	Female	All	+0.758	<.001	11	view →
COAD	Male	IV	+0.731	<.001	10	view →
LUSC	Female	II,III,IV	−0.952	<.001	8	view →
LIHC	Female	II,III,IV	+0.669	<.001	7	view →
KIRP	All	IV	+1.035	.013	6	view →
BRCA	All	III,IV	−0.650	<.001	6	view →
CHOL	All	All	+1.734	<.001	5	view →
LUAD	Female	All	−0.604	<.001	5	view →
STAD	Male	II,III,IV	+0.871	.004	4	view →
UCEC	All	All	−0.714	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NOD1–THCA

Open the THCA breakdown →