NOD1

Across TCGA patient cohorts, NOD1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOD1-associated genes across cancer lineages are eIF4E, Notch1, and PDCD4. Each is linked with NOD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NOD1-to-partner and partner-to-NOD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NOD1-low versus NOD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOD1→partner) and Y-score (partner→NOD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.162	+1.678	.026	.021	3	4
UCEC	Notch1 →	+0.170	+2.128	<.001	.009	3	3
UCEC	PDCD4 →	-0.536	-2.584	<.001	.010	3	3
COAD	GAPDH →	+0.570	+2.820	.030	.035	3	2
COAD	ASNS →	+0.600	+3.008	.003	.019	3	2
UCEC	ERK2 →	+0.167	+1.700	.012	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eIF4E by NOD1 expression — UCEC

Explore this box plot interactively →