NOD1

Across TCGA cell cohorts, NOD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,868 significant associations in total. CNS shows the largest number of these associations.

The most reproducible NOD1-associated GO terms across cancer lineages are Nucleotide-binding oligomerization domain containing 1 signaling pathway, Protein targeting to vacuole, and Regulation of translational initiation. Each is linked with NOD1 in more than 14 cancer types. Because this analysis shows association rather than direction, both NOD1-to-partner and partner-to-NOD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleotide-binding oligomerization domain containing 1 signaling pathway grouped by NOD1-low versus NOD1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NOD1→partner) and Y-score (partner→NOD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Nucleotide-binding oligomerization domain containing 1 signaling pathway →	+0.635	+1.667	.002	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Protein targeting to vacuole →	+0.081	+0.803	<.001	<.001	3	12
CNS	Regulation of translational initiation →	+0.063	+0.620	<.001	<.001	3	11
KIDNEY	Meiotic attachment of telomere to nuclear envelope →	+0.178	+0.899	<.001	<.001	3	11
KIDNEY	Meiotic telomere tethering at nuclear periphery →	+0.178	+0.899	<.001	<.001	3	11
KIDNEY	Meiotic telomere clustering →	+0.178	+0.899	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,868 associations by consensus.

Nucleotide-binding oligomerization domain containing 1 signaling pathway by NOD1 expression — LUNG_SCLC

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