NOD1

Across TCGA cell cohorts, NOD1 mutation is significantly associated with the RNA expression of many other genes, with 474 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOD1-associated genes across cancer lineages are METTL14, CCR8, and CLPS. Each is linked with NOD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOD1-to-partner and partner-to-NOD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL14 grouped by NOD1-low versus NOD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOD1→partner) and Y-score (partner→NOD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	METTL14 →	+0.532	+3.502	.005	.001	3	2
BLOOD_Leukemia	CCR8 →	+1.623	+3.385	.003	.008	3	2
SOFT_TISSUE	CLPS →	+0.114	+4.977	<.001	.002	3	1
SOFT_TISSUE	CABS1 →	+0.072	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR52J3 →	+0.019	+4.369	<.001	.008	3	1
SOFT_TISSUE	CARD17 →	+0.282	+4.977	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 474 associations by consensus.

METTL14 by NOD1 expression — LARGE_INTESTINE

Explore this box plot interactively →