NOC3L

Across TCGA pan-cancer cohorts, NOC3L mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NOC3L data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NOC3L mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NOC3L expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where NOC3L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.401	0.786	.001	47	view →
PDAC	OS	Tertile	II,III,IV	0.248	0.549	.003	21	view →
LUAD	DFS	Median	III,IV	0.783	0.269	.003	16	view →
LSCC	DFS	Median	II,III,IV	0.830	0.534	.013	7	view →
CCRCC	DFS	Quartile	III,IV	0.397	0.737	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NOC3L–HNSC (DFS)

Open the HNSC breakdown →