NOC3L

Across TCGA pan-cancer cohorts, NOC3L RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NOC3L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where NOC3L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NOC3L is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRP, LUAD, and HNSC are the cancer types where NOC3L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOC3L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.641	<.001	11	view →
LUAD	Male	II,III,IV	+0.846	<.001	10	view →
HNSC	All	IV	+0.625	<.001	10	view →
LIHC	All	III,IV	+0.827	<.001	9	view →
KIRC	Male	All	+0.470	<.001	9	view →
COAD	Female	II,III,IV	+1.127	<.001	8	view →
BLCA	All	III,IV	+0.644	.001	8	view →
STAD	All	II,III,IV	+1.036	<.001	7	view →
KICH	Female	II,III,IV	−1.288	<.001	6	view →
CHOL	All	All	+1.778	<.001	5	view →
READ	All	III,IV	+1.509	<.001	5	view →
LUSC	Male	II,III,IV	+0.859	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NOC3L–KIRP

Open the KIRP breakdown →