NOC3L

Across TCGA patient cohorts, NOC3L mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOC3L-associated genes across cancer lineages are 53BP1, p38-MAPK_pT180_Y182, and Rad50. Each is linked with NOC3L in more than 2 cancer types. Because this analysis shows association rather than direction, both NOC3L-to-partner and partner-to-NOC3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 53BP1 grouped by NOC3L-low versus NOC3L-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOC3L→partner) and Y-score (partner→NOC3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	53BP1 →	+0.554	+3.017	.003	.019	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.372	-2.321	.015	.033	3	2
UCEC	Rad50 →	-0.176	-1.247	.032	.045	3	2
UCEC	STAT3_pY705 →	-0.375	-1.514	<.001	.015	3	2
UCEC	Tuberin →	+0.312	+2.700	<.001	.005	3	2
UCEC	beta-Catenin →	+0.364	+2.000	.035	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

53BP1 by NOC3L expression — BLCA

Explore this box plot interactively →