NOC3L

Across TCGA cell cohorts, NOC3L mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NOC3L-associated genes across cancer lineages are OR52B2, AVP, and MAGEB4. Each is linked with NOC3L in more than 1 cancer types. Because this analysis shows association rather than direction, both NOC3L-to-partner and partner-to-NOC3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52B2 grouped by NOC3L-low versus NOC3L-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOC3L→partner) and Y-score (partner→NOC3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR52B2 →	+0.048	+4.981	<.001	.008	3	1
LARGE_INTESTINE	AVP →	+0.048	+3.217	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	LRRC3C →	+0.253	+3.099	.001	.004	3	1
SKIN	GALR1 →	+0.972	+5.022	<.001	.002	3	1
BLOOD_Lymphoma	PRSS54 →	+0.046	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR52B2 by NOC3L expression — CNS

Explore this box plot interactively →