NOBOX

Across TCGA pan-cancer cohorts, NOBOX Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NOBOX data layer compared with 14 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NOBOX Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NOBOX expression acts as an unfavorable survival marker.

COAD, KIRC, and LUSC are the cancer types where NOBOX Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	II,III,IV	0.111	0.853	<.001	18	view →
KIRC	OS	Median	All	0.125	0.881	<.001	12	view →
LUSC	OS	Median	IV	0.001	0.673	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NOBOX–COAD (OS)

Open the COAD breakdown →