NOA1

Across TCGA cell cohorts, NOA1 mutation is significantly associated with the RNA expression of many other genes, with 401 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NOA1-associated genes across cancer lineages are GDF3, OR4E2, and NPVF. Each is linked with NOA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOA1-to-partner and partner-to-NOA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GDF3 grouped by NOA1-low versus NOA1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOA1→partner) and Y-score (partner→NOA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GDF3 →	+0.135	+5.169	<.001	.005	3	1
BREAST	OR4E2 →	+0.025	+5.169	<.001	.005	3	1
LUNG_NSCLC_LUAD	NPVF →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4D5 →	+0.014	+4.662	<.001	.005	3	1
LARGE_INTESTINE	SAMM50 →	+0.603	+3.064	<.001	.009	3	1
LARGE_INTESTINE	TNRC6B →	+0.849	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 401 associations by consensus.

GDF3 by NOA1 expression — BREAST

Explore this box plot interactively →