NNT

Across TCGA patient cohorts, NNT mutation is significantly associated with the RNA expression of many other genes, with 1,977 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NNT-associated genes across cancer lineages are FAXDC2, PSMA4, and RNA5SP106. Each is linked with NNT in more than 2 cancer types. Because this analysis shows association rather than direction, both NNT-to-partner and partner-to-NNT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAXDC2 grouped by NNT-low versus NNT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NNT→partner) and Y-score (partner→NNT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAXDC2 →	-0.675	-3.796	<.001	<.001	3	3
UCEC	PSMA4 →	+0.344	+1.546	.009	.009	3	3
PRAD	RNA5SP106 →	+0.303	+7.939	<.001	.008	3	3
UCEC	PGAM5 →	+0.582	+2.137	<.001	.001	3	3
UCEC	RFC5 →	+0.510	+1.557	<.001	.009	3	3
LUSC	RPS29P33 →	+0.274	+4.502	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,977 associations by consensus.

FAXDC2 by NNT expression — UCEC

Explore this box plot interactively →