NNT

Across TCGA pan-cancer cohorts, NNT RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NNT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NNT RNA is repressed in tumor relative to normal tissue. In most cancer types NNT is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LUAD are the cancer types where NNT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NNT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	−1.350	<.001	11	view →
THCA	Male	III,IV	−1.271	<.001	10	view →
LUAD	Male	III,IV	+0.760	.001	6	view →
KICH	All	All	+1.005	<.001	5	view →
COAD	All	All	−0.377	.005	5	view →
LUSC	All	All	+0.534	<.001	3	view →
CHOL	Male	All	−1.446	.022	2	view →
READ	All	All	−0.983	.036	2	view →
BLCA	Male	IV	−0.884	.023	2	view →
PRAD	All	All	−0.615	<.001	2	view →
BRCA	All	IV	+0.525	.031	2	view →
LUSC	All	III,IV	−0.813	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

NNT–KIRC

Open the KIRC breakdown →