NNT

Across TCGA patient cohorts, NNT mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NNT-associated genes across cancer lineages are TFRC, VEGFR2, and ASNS. Each is linked with NNT in more than 1 cancer types. Because this analysis shows association rather than direction, both NNT-to-partner and partner-to-NNT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by NNT-low versus NNT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NNT→partner) and Y-score (partner→NNT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.593	+3.584	.001	.002	3	2
UCEC	VEGFR2 →	+0.235	+1.598	.028	.011	3	2
UCEC	ASNS →	+0.400	+1.584	.002	.034	3	2
UCEC	4E-BP1 →	+0.332	+2.730	<.001	.003	3	2
UCEC	C-Raf →	+0.129	+2.906	.012	.001	3	2
UCEC	Cyclin-E2 →	+0.173	+1.817	.004	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

TFRC by NNT expression — UCEC

Explore this box plot interactively →