NNT

Across TCGA cell cohorts, NNT mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NNT-associated genes across cancer lineages are RASGEF1C, GSG1L2, and KLRD1. Each is linked with NNT in more than 1 cancer types. Because this analysis shows association rather than direction, both NNT-to-partner and partner-to-NNT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RASGEF1C grouped by NNT-low versus NNT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NNT→partner) and Y-score (partner→NNT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RASGEF1C →	+0.237	+3.333	.002	.009	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
BLOOD_Leukemia	KLRD1 →	+0.262	+3.769	<.001	.008	3	1
BLOOD_Leukemia	ODF1 →	+0.064	+3.944	.001	.006	3	1
BLOOD_Leukemia	ZIC3 →	+0.015	+4.060	<.001	.003	3	1
BLOOD_Leukemia	DCLK3 →	+0.258	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

RASGEF1C by NNT expression — LARGE_INTESTINE

Explore this box plot interactively →