NNMT

Across TCGA pan-cancer cohorts, NNMT mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of NNMT’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where NNMT mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NNMT is over-expressed in tumor.

CCRCC, COAD, and HNSC are the cancer types where NNMT tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NNMT mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	+2.997	<.001	12	view →
COAD	Female	III,IV	+1.256	<.001	11	view →
HNSC	Male	IV	+1.140	<.001	11	view →
LUAD	Male	III,IV	+1.717	<.001	9	view →
LSCC	All	III,IV	+0.742	<.001	9	view →
PDAC	Female	All	+1.194	<.001	8	view →
OV	All	All	+0.862	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

NNMT–CCRCC

Open the CCRCC breakdown →