NNMT

Across TCGA patient cohorts, NNMT mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NNMT-associated genes across cancer lineages are VHL, EGFR, and JNK2. Each is linked with NNMT in more than 1 cancer types. Because this analysis shows association rather than direction, both NNMT-to-partner and partner-to-NNMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by NNMT-low versus NNMT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NNMT→partner) and Y-score (partner→NNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.424	-3.906	<.001	<.001	3	2
UCEC	EGFR →	-0.198	-2.115	.004	.019	3	1
UCEC	JNK2 →	+0.272	+2.807	.001	.003	3	1
UCEC	Ku80 →	+0.253	+2.128	.014	.010	3	1
UCEC	MEK1 →	+0.625	+3.906	<.001	<.001	3	1
UCEC	p90 RSK_pT359_S363 →	-0.231	-2.321	.008	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

VHL by NNMT expression — UCEC

Explore this box plot interactively →