NMT1

Across TCGA cell cohorts, NMT1 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NMT1-associated genes across cancer lineages are OR1J4, PHOX2B, and IQCF5. Each is linked with NMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NMT1-to-partner and partner-to-NMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1J4 grouped by NMT1-low versus NMT1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMT1→partner) and Y-score (partner→NMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR1J4 →	+0.148	+3.948	<.001	.003	3	2
LARGE_INTESTINE	PHOX2B →	+0.041	+4.362	<.001	.005	3	2
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.042	+4.357	<.001	.006	3	2
BLOOD_Leukemia	PAX1 →	+0.024	+3.475	.001	.006	3	1
BLOOD_Leukemia	GSC →	+1.056	+3.948	<.001	.003	3	1
BLOOD_Leukemia	BRDT →	+0.147	+3.342	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

OR1J4 by NMT1 expression — BLOOD_Leukemia

Explore this box plot interactively →