NMRK2

Across TCGA patient cohorts, NMRK2 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NMRK2-associated genes across cancer lineages are ANAPC1P3, LINC01955, and GOLGA6D. Each is linked with NMRK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NMRK2-to-partner and partner-to-NMRK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANAPC1P3 grouped by NMRK2-low versus NMRK2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMRK2→partner) and Y-score (partner→NMRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ANAPC1P3 →	+0.228	+5.533	<.001	<.001	3	2
HNSC	LINC01955 →	+0.070	+5.182	<.001	.007	3	1
HNSC	GOLGA6D →	+0.011	+5.069	<.001	.008	3	1
HNSC	RNU6-12P →	+0.423	+5.124	<.001	.008	3	1
UCEC	RPL23AP90 →	+0.361	+4.007	.006	<.001	3	1
UCEC	RNA5SP414 →	+0.983	+2.670	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

ANAPC1P3 by NMRK2 expression — SKCM

Explore this box plot interactively →