NMRK1

Across TCGA patient cohorts, NMRK1 mutation is significantly associated with the RNA expression of many other genes, with 1,070 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NMRK1-associated genes across cancer lineages are LACRT, NEUROD6, and DEFB109B. Each is linked with NMRK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NMRK1-to-partner and partner-to-NMRK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LACRT grouped by NMRK1-low versus NMRK1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMRK1→partner) and Y-score (partner→NMRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LACRT →	+0.159	+4.539	<.001	.008	3	1
CESC	NEUROD6 →	+0.018	+4.812	<.001	.006	3	1
CESC	DEFB109B →	+0.148	+4.969	<.001	.004	3	1
CESC	RNU6-15P →	+0.603	+4.364	<.001	.006	3	1
CESC	RNA5SP198 →	+0.277	+5.144	<.001	.003	3	1
CESC	OR7E101P →	+0.139	+4.705	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,070 associations by consensus.

LACRT by NMRK1 expression — CESC

Explore this box plot interactively →