NMNAT3

Across TCGA patient cohorts, NMNAT3 mutation is significantly associated with the RNA expression of many other genes, with 1,423 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NMNAT3-associated genes across cancer lineages are H2AC14, CBY1, and DESI1. Each is linked with NMNAT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NMNAT3-to-partner and partner-to-NMNAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AC14 grouped by NMNAT3-low versus NMNAT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NMNAT3→partner) and Y-score (partner→NMNAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H2AC14 →	+1.180	+3.601	<.001	.001	3	2
SKCM	CBY1 →	+0.433	+3.729	<.001	<.001	3	2
SKCM	DESI1 →	+0.375	+3.689	.003	.001	3	2
SKCM	KXD1 →	+0.367	+2.547	<.001	.001	3	2
SKCM	RPA3 →	+0.569	+2.738	<.001	.002	3	2
SKCM	PSMD9 →	+0.286	+2.031	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,423 associations by consensus.

H2AC14 by NMNAT3 expression — UCEC

Explore this box plot interactively →