NMNAT3

Across TCGA pan-cancer cohorts, NMNAT3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NMNAT3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NMNAT3 RNA is repressed in tumor relative to normal tissue. In most cancer types NMNAT3 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and LUSC are the cancer types where NMNAT3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NMNAT3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.627	<.001	11	view →
LUAD	All	II,III,IV	−0.586	<.001	7	view →
LUSC	Female	All	+1.572	<.001	6	view →
UCEC	All	All	−1.362	<.001	6	view →
COAD	Female	All	+0.987	<.001	6	view →
KIRC	Male	II,III,IV	−0.627	<.001	6	view →
LIHC	Male	All	+0.545	<.001	6	view →
STAD	Male	II,III,IV	+0.832	.006	4	view →
BRCA	Female	All	−0.478	<.001	4	view →
CHOL	Female	All	+2.193	<.001	3	view →
KICH	All	All	−0.590	.008	2	view →
PRAD	All	All	−0.271	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NMNAT3–THCA

Open the THCA breakdown →