NME9

Across TCGA patient cohorts, NME9 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NME9-associated genes across cancer lineages are Caspase-8, ERK2, and Ku80. Each is linked with NME9 in more than 1 cancer types. Because this analysis shows association rather than direction, both NME9-to-partner and partner-to-NME9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by NME9-low versus NME9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NME9→partner) and Y-score (partner→NME9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.262	-1.973	.014	.029	3	2
UCEC	ERK2 →	+0.181	+1.700	.027	.044	3	1
UCEC	Ku80 →	+0.250	+1.713	.012	.027	3	1
UCEC	Notch1 →	+0.142	+2.183	.017	.033	3	1
UCEC	p62 Lck ligand →	+0.295	+2.179	.032	.034	3	1
UCEC	PCNA →	+0.190	+2.222	.038	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Caspase-8 by NME9 expression — UCEC

Explore this box plot interactively →