NME9

Across TCGA pan-cancer cohorts, NME9 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NME9 data layer compared with 7 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher NME9 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NME9 expression acts as an unfavorable survival marker, although some lineages such as BRCA and BLCA show a favorable association.

BRCA, BLCA, and KIRP are the cancer types where NME9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Tertile	All	0.630	0.424	<.001	98	view →
BLCA	OS	Tertile	All	0.597	0.362	<.001	34	view →
KIRP	DFS	Tertile	All	1.000	0.745	.004	29	view →
COAD	DFS	Tertile	II,III,IV	0.531	0.691	.007	29	view →
UVM	DFS	Quartile	All	0.300	0.906	.021	18	view →
READ	OS	Median	All	0.780	0.340	.009	13	view →
HNSC	DFS	Quartile	II,III,IV	0.773	0.639	.019	13	view →
UCS	DFS	Tertile	IV	0.956	0.510	.024	12	view →
CESC	OS	Median	IV	0.838	0.378	.008	12	view →
MESO	DFS	Median	IV	0.186	0.481	.017	9	view →
LUAD	DFS	Tertile	IV	0.404	0.931	.017	6	view →
SCLC	DFS	Tertile	IV	0.183	0.776	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NME9–BRCA (DFS)

Open the BRCA breakdown →