NME2P1

Across TCGA patient cohorts, NME2P1 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NME2P1-associated genes across cancer lineages are RNU6-1078P, RNU6-159P, and RPL27P8. Each is linked with NME2P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NME2P1-to-partner and partner-to-NME2P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1078P grouped by NME2P1-low versus NME2P1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NME2P1→partner) and Y-score (partner→NME2P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-1078P →	+0.278	+7.954	<.001	.008	3	1
HNSC	RNU6-159P →	+0.274	+7.954	<.001	.008	3	1
BLCA	RPL27P8 →	+0.198	+3.130	<.001	.007	3	1
BLCA	RPL32P8 →	+0.122	+3.266	.001	.009	3	1
BLCA	HMGN1P14 →	+0.442	+3.691	<.001	.001	3	1
BLCA	P3R3URF →	+0.070	+4.122	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

RNU6-1078P by NME2P1 expression — HNSC

Explore this box plot interactively →