NLRP8

Across TCGA patient cohorts, NLRP8 mutation is significantly associated with the RNA expression of many other genes, with 4,409 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NLRP8-associated genes across cancer lineages are GEMIN2, TSPOAP1, and CRTAC1. Each is linked with NLRP8 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLRP8-to-partner and partner-to-NLRP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GEMIN2 grouped by NLRP8-low versus NLRP8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP8→partner) and Y-score (partner→NLRP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GEMIN2 →	+0.499	+2.013	<.001	.005	3	4
UCEC	TSPOAP1 →	-0.709	-3.215	<.001	<.001	3	4
LUAD	CRTAC1 →	-1.492	-1.999	<.001	.009	3	4
HNSC	SNRPD3 →	+0.323	+3.584	.004	.002	3	4
HNSC	SNW1 →	+0.381	+2.596	.001	.005	3	4
HNSC	SPATA5L1 →	+0.356	+3.459	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,409 associations by consensus.

GEMIN2 by NLRP8 expression — COAD

Explore this box plot interactively →