NLRP8

Across TCGA pan-cancer cohorts, NLRP8 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated NLRP8 data layer compared with 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher NLRP8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NLRP8 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SCLC show a favorable association.

LUSC, OV, and THCA are the cancer types where NLRP8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	IV	0.001	0.673	.014	48	view →
OV	DFS	Tertile	All	0.317	0.401	.008	36	view →
THCA	DFS	Tertile	III,IV	0.631	0.849	.001	27	view →
KIRC	DFS	Quartile	III,IV	0.277	0.547	.009	26	view →
BRCA	OS	Tertile	III,IV	0.952	0.869	.013	17	view →
SCLC	OS	Tertile	All	0.868	0.644	.015	15	view →
STAD	DFS	Tertile	IV	0.130	0.503	.001	15	view →
BLCA	DFS	Tertile	IV	0.187	0.387	.040	15	view →
LIHC	OS	Tertile	III,IV	0.181	0.364	.040	9	view →
ESCA	DFS	Quartile	III,IV	0.598	0.274	.016	8	view →
UCS	OS	Tertile	All	0.830	0.515	.043	6	view →
LGG	OS	Tertile	All	0.731	0.829	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

NLRP8–LUSC (OS)

Open the LUSC breakdown →