NLRP8

Across TCGA patient cohorts, NLRP8 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP8-associated genes across cancer lineages are p27_pT157, Cyclin-B1, and ERK2. Each is linked with NLRP8 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLRP8-to-partner and partner-to-NLRP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by NLRP8-low versus NLRP8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP8→partner) and Y-score (partner→NLRP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	p27_pT157 →	+0.059	+1.307	.041	.034	3	4
LUAD	Cyclin-B1 →	+0.735	+2.321	.001	.035	3	4
UCEC	ERK2 →	+0.140	+1.473	.017	.006	3	4
UCEC	JNK_pT183_Y185 →	-0.109	-1.584	.034	.034	3	4
LUSC	Raptor →	+0.162	+1.714	.022	.024	3	3
COAD	mTOR_pS2448 →	-0.200	-2.309	.004	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

p27_pT157 by NLRP8 expression — LUSC

Explore this box plot interactively →