NLRP8

Across TCGA cell cohorts, NLRP8 RNA expression is significantly associated with the mutation status of many other genes, with 182 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NLRP8-associated genes across cancer lineages are KALRN, INSR, and HIP1. Each is linked with NLRP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP8-to-partner and partner-to-NLRP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KALRN grouped by NLRP8-low versus NLRP8-high in SOFT_TISSUE.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP8→partner) and Y-score (partner→NLRP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KALRN →	+3.977	+0.003	.007	<.001	3	2
OESOPHAGUS	INSR →	+4.906	+0.006	.006	<.001	3	2
LUNG_NSCLC_LUSC	HIP1 →	+4.643	+0.023	.008	<.001	3	2
OESOPHAGUS	LPA →	+4.906	+0.006	.006	<.001	3	2
BLOOD_Lymphoma	ANPEP →	+4.867	+0.072	.009	<.001	3	2
BLOOD_Lymphoma	LGR4 →	+4.867	+0.041	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 182 associations by consensus.

KALRN by NLRP8 expression — SOFT_TISSUE

Explore this box plot interactively →