NLRP8

Across TCGA cell cohorts, NLRP8 mutation is significantly associated with the RNA expression of many other genes, with 234 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRP8-associated genes across cancer lineages are ZFYVE21, ADH5, and IFNL4. Each is linked with NLRP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP8-to-partner and partner-to-NLRP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZFYVE21 grouped by NLRP8-low versus NLRP8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP8→partner) and Y-score (partner→NLRP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZFYVE21 →	+0.509	+3.628	.002	<.001	3	2
SKIN	ADH5 →	+0.426	+2.502	.003	.005	3	2
SKIN	IFNL4 →	+0.026	+2.204	.001	.005	3	2
BREAST	OR1N2 →	+0.046	+4.199	<.001	.007	3	2
BONE	GP9 →	+0.049	+5.169	<.001	.004	3	1
SOFT_TISSUE	OR4X2 →	+0.026	+4.954	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 234 associations by consensus.

ZFYVE21 by NLRP8 expression — SKIN

Explore this box plot interactively →