NLRP5

Across TCGA patient cohorts, NLRP5 mutation is significantly associated with the RNA expression of many other genes, with 5,275 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP5-associated genes across cancer lineages are MYO19, PSMC3IP, and RAD18. Each is linked with NLRP5 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLRP5-to-partner and partner-to-NLRP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO19 grouped by NLRP5-low versus NLRP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP5→partner) and Y-score (partner→NLRP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYO19 →	+0.464	+1.854	<.001	<.001	3	4
UCEC	PSMC3IP →	+0.531	+1.349	<.001	<.001	3	4
UCEC	RAD18 →	+0.291	+1.516	.001	.002	3	4
UCEC	HAUS8 →	+0.324	+1.970	.001	<.001	3	4
LUAD	CDCA8 →	+0.654	+2.193	<.001	.001	3	4
LUAD	WDR12 →	+0.261	+1.797	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,275 associations by consensus.

MYO19 by NLRP5 expression — UCEC

Explore this box plot interactively →