NLRP4

Across TCGA patient cohorts, NLRP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,842 significant associations in total. STAD shows the largest number of these associations.

The most reproducible NLRP4-associated GO terms across cancer lineages are Regulation of production of molecular mediator of immune response, Immune system development, and Positive regulation of canonical NF-kappaB signal transduction. Each is linked with NLRP4 in more than 18 cancer types. Because this analysis shows association rather than direction, both NLRP4-to-partner and partner-to-NLRP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of production of molecular mediator of immune response grouped by NLRP4-low versus NLRP4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP4→partner) and Y-score (partner→NLRP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of production of molecular mediator of immune response →	+0.077	+0.321	<.001	<.001	3	19
STAD	Immune system development →	+0.095	+0.486	<.001	<.001	3	18
STAD	Positive regulation of canonical NF-kappaB signal transduction →	+0.089	+0.346	<.001	<.001	3	18
STAD	Regulation of lymphocyte differentiation →	+0.093	+0.411	<.001	<.001	2	19
STAD	Regulation of B cell activation →	+0.068	+0.272	<.001	<.001	3	18
ESCA	Nuclear export →	+0.085	+0.369	<.001	.003	2	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,842 associations by consensus.

Regulation of production of molecular mediator of immune response by NLRP4 expression — STAD

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