NLRP4

Across TCGA cell cohorts, NLRP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 921 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NLRP4-associated GO terms across cancer lineages are RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, mRNA splicing, via spliceosome, and Immunoglobulin production. Each is linked with NLRP4 in more than 6 cancer types. Because this analysis shows association rather than direction, both NLRP4-to-partner and partner-to-NLRP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile grouped by NLRP4-low versus NLRP4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP4→partner) and Y-score (partner→NLRP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.056	+0.035	<.001	.006	3	7
BREAST	mRNA splicing, via spliceosome →	+0.056	+0.035	<.001	.006	3	7
LUNG_NSCLC_LUSC	Immunoglobulin production →	+0.048	+0.062	.002	.008	3	6
SKIN	Mitochondrial electron transport, ubiquinol to cytochrome c →	+0.059	+0.496	<.001	.005	3	6
BREAST	RNA splicing, via transesterification reactions →	+0.056	+0.040	<.001	.002	3	5
LUNG_NSCLC_LUSC	Regulation of RNA splicing →	+0.048	+0.062	.003	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 921 associations by consensus.

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile by NLRP4 expression — BREAST

Explore this box plot interactively →