NLRP2

Across TCGA patient cohorts, NLRP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,820 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible NLRP2-associated GO terms across cancer lineages are Macrophage differentiation, CD4-positive, alpha-beta T cell activation, and Response to interleukin-4. Each is linked with NLRP2 in more than 11 cancer types. Because this analysis shows association rather than direction, both NLRP2-to-partner and partner-to-NLRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macrophage differentiation grouped by NLRP2-low versus NLRP2-high in SARC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP2→partner) and Y-score (partner→NLRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	Macrophage differentiation →	+0.031	+0.563	<.001	<.001	3	12
SKCM	CD4-positive, alpha-beta T cell activation →	+0.043	+0.680	<.001	<.001	3	12
SKCM	Response to interleukin-4 →	+0.041	+0.720	<.001	<.001	3	11
SKCM	Tumor necrosis factor superfamily cytokine production →	+0.042	+0.651	<.001	<.001	3	11
SKCM	Positive regulation of leukocyte cell-cell adhesion →	+0.047	+0.504	<.001	<.001	3	11
KIRC	Negative regulation of innate immune response →	+0.039	+0.382	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,820 associations by consensus.

Macrophage differentiation by NLRP2 expression — SARC

Explore this box plot interactively →