NLRP2

Across TCGA pan-cancer cohorts, NLRP2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NLRP2 data layer compared with 10 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher NLRP2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NLRP2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KICH show a favorable association.

PAAD, UCS, and UCEC are the cancer types where NLRP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Tertile	All	0.292	0.661	<.001	57	view →
UCS	OS	Median	All	0.530	0.819	<.001	50	view →
UCEC	OS	Tertile	All	0.828	0.906	.010	28	view →
SKCM	OS	Tertile	All	0.408	0.250	.004	27	view →
SCLC	DFS	Quartile	All	0.354	0.881	<.001	25	view →
KICH	DFS	Tertile	All	1.000	0.596	.017	23	view →
THYM	OS	Median	II,III,IV	0.955	0.686	.003	19	view →
LUAD	OS	Median	All	0.852	0.769	.003	12	view →
KIRP	OS	Quartile	II,III,IV	0.861	0.450	.007	12	view →
LGG	OS	Median	All	0.726	0.864	.002	11	view →
ACC	DFS	Quartile	III,IV	0.133	0.565	.023	10	view →
READ	OS	Quartile	III,IV	0.447	0.955	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NLRP2–PAAD (OS)

Open the PAAD breakdown →