NLRP2

Across TCGA patient cohorts, NLRP2 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP2-associated genes across cancer lineages are Caspase-7-cleavedD198, STAT3_pY705, and Cyclin-B1. Each is linked with NLRP2 in more than 4 cancer types. Because this analysis shows association rather than direction, both NLRP2-to-partner and partner-to-NLRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NLRP2-low versus NLRP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP2→partner) and Y-score (partner→NLRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.433	+1.434	.024	.027	3	5
UCEC	STAT3_pY705 →	-0.383	-2.169	<.001	.002	3	4
LUAD	Cyclin-B1 →	+0.743	+3.321	<.001	.009	3	4
UCEC	C-Raf →	+0.144	+1.765	.001	.013	3	4
UCEC	RBM15 →	+0.204	+1.906	.048	.015	3	4
UCEC	MEK1 →	+0.425	+2.000	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Caspase-7-cleavedD198 by NLRP2 expression — UCEC

Explore this box plot interactively →