NLRP2

Across TCGA cell cohorts, NLRP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,764 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NLRP2-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, rRNA metabolic process, and tRNA aminoacylation for protein translation. Each is linked with NLRP2 in more than 5 cancer types. Because this analysis shows association rather than direction, both NLRP2-to-partner and partner-to-NLRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by NLRP2-low versus NLRP2-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP2→partner) and Y-score (partner→NLRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of syncytium formation by plasma membrane fusion →	+0.054	+1.590	<.001	.001	3	6
BLOOD_Myeloma	rRNA metabolic process →	+0.100	+2.826	<.001	.002	3	5
BLOOD_Myeloma	tRNA aminoacylation for protein translation →	+0.096	+2.731	<.001	.003	3	5
BREAST	Sodium ion transport →	-0.036	-1.939	.008	.001	3	5
LUNG_NSCLC_LUAD	Regulation of modification of postsynaptic actin cytoskeleton →	+0.107	+1.843	.003	.008	3	5
LUNG_NSCLC_LUAD	snRNA pseudouridine synthesis →	+0.039	+2.039	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,764 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by NLRP2 expression — BLOOD_Lymphoma

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