NLRP2

Across TCGA cell cohorts, NLRP2 mutation is significantly associated with the RNA expression of many other genes, with 359 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRP2-associated genes across cancer lineages are MFAP3L, C5orf46, and KAAG1. Each is linked with NLRP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP2-to-partner and partner-to-NLRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MFAP3L grouped by NLRP2-low versus NLRP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP2→partner) and Y-score (partner→NLRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MFAP3L →	+1.235	+3.743	<.001	<.001	3	2
BLOOD_Lymphoma	C5orf46 →	+0.055	+3.843	.007	.007	3	2
BLOOD_Leukemia	KAAG1 →	+0.070	+3.177	<.001	.004	3	2
BLOOD_Leukemia	CFHR2 →	+0.174	+4.124	<.001	<.001	3	2
SKIN	PKHD1L1 →	+0.065	+2.004	<.001	.007	3	2
LARGE_INTESTINE	TTI2 →	+0.623	+3.459	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 359 associations by consensus.

MFAP3L by NLRP2 expression — LARGE_INTESTINE

Explore this box plot interactively →