NLRP13

Across TCGA pan-cancer cohorts, NLRP13 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NLRP13 data layer compared with 13 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher NLRP13 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NLRP13 expression acts as an unfavorable survival marker, although some lineages such as STAD and SKCM show a favorable association.

KIRP, GBM, and STAD are the cancer types where NLRP13 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.135	0.703	.002	12	view →
GBM	DFS	Median	All	0.046	0.258	<.001	6	view →
STAD	OS	Median	IV	0.805	0.283	.031	6	view →
SKCM	OS	Median	III,IV	0.914	0.771	.017	4	view →
LIHC	DFS	Median	All	0.162	0.533	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NLRP13–KIRP (OS)

Open the KIRP breakdown →