NLRP12

Across TCGA cell cohorts, NLRP12 mutation is significantly associated with the RNA expression of many other genes, with 166 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRP12-associated genes across cancer lineages are NKX2-6, ACER1, and VWC2L. Each is linked with NLRP12 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP12-to-partner and partner-to-NLRP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by NLRP12-low versus NLRP12-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP12→partner) and Y-score (partner→NLRP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.362	+4.201	<.001	.001	3	2
LARGE_INTESTINE	ACER1 →	+0.065	+2.394	<.001	<.001	3	2
BLOOD_Leukemia	VWC2L →	+0.013	+3.339	<.001	.006	3	2
BLOOD_Leukemia	TMEM26 →	+0.875	+3.623	.001	.007	3	2
BLOOD_Leukemia	C13orf42 →	+0.037	+4.007	<.001	.002	3	2
SOFT_TISSUE	KRTAP17-1 →	+0.019	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 166 associations by consensus.

NKX2-6 by NLRP12 expression — BLOOD_Leukemia

Explore this box plot interactively →