NLRP1

Across TCGA cell cohorts, NLRP1 mutation is significantly associated with the RNA expression of many other genes, with 1,356 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRP1-associated genes across cancer lineages are MARCHF11, KCNH7, and FBXO7. Each is linked with NLRP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NLRP1-to-partner and partner-to-NLRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MARCHF11 grouped by NLRP1-low versus NLRP1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP1→partner) and Y-score (partner→NLRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MARCHF11 →	+0.214	+3.836	.001	.004	3	2
BLOOD_Lymphoma	KCNH7 →	+0.825	+4.505	<.001	.003	3	2
SKIN	FBXO7 →	+0.616	+2.451	.006	<.001	3	2
SKIN	CEP85L →	+0.589	+2.364	.002	<.001	3	2
SKIN	GAS2L3 →	+0.730	+1.850	.009	.006	3	2
SKIN	OAZ2 →	+0.320	+2.364	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,356 associations by consensus.

MARCHF11 by NLRP1 expression — OESOPHAGUS

Explore this box plot interactively →