NLRC4

Across TCGA pan-cancer cohorts, NLRC4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NLRC4 data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NLRC4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated NLRC4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and TGCT are the cancer types where NLRC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.848	0.624	.002	36	view →
HNSC	DFS	Median	II,III,IV	0.240	0.615	.006	12	view →
TGCT	DFS	Median	All	0.146	0.801	.020	6	view →
SKCM	OS	Median	IV	0.415	0.861	.014	5	view →
LGG	OS	Median	All	0.585	0.891	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NLRC4–UCEC (DFS)

Open the UCEC breakdown →